Ivan Bièche Selected Research

Cetuximab (Erbitux)

12/2021	Phase I trial of copanlisib, a selective PI3K inhibitor, in combination with cetuximab in patients with recurrent and/or metastatic head and neck squamous cell carcinoma.
4/2015	Evaluating patient-derived colorectal cancer xenografts as preclinical models by comparison with patient clinical data.

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Ivan Bièche Research Topics

Disease

87	Neoplasms (Cancer) 05/2024 - 03/2002
67	Breast Neoplasms (Breast Cancer) 05/2024 - 03/2002
21	Neoplasm Metastasis (Metastasis) 10/2021 - 04/2006
20	Carcinogenesis 01/2023 - 03/2002
11	Triple Negative Breast Neoplasms 10/2023 - 01/2012
10	Plexiform Neurofibroma 10/2022 - 06/2004
8	Carcinoma (Carcinomatosis) 11/2019 - 09/2007
7	Fibrosis (Cirrhosis) 01/2020 - 02/2005
6	Neurofibrosarcoma (MPNST) 10/2022 - 06/2004
4	Squamous Cell Carcinoma of Head and Neck 12/2023 - 12/2019
4	Neurofibromatosis 1 (Neurofibromatosis Type I) 07/2023 - 01/2007
4	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 12/2022 - 09/2003
4	Neurofibroma 10/2022 - 06/2004
3	Chordoma 11/2023 - 01/2022
3	Residual Neoplasm 11/2021 - 01/2016
3	Sarcoma (Soft Tissue Sarcoma) 11/2019 - 03/2011
3	Alzheimer Disease (Alzheimer's Disease) 01/2017 - 08/2015
3	Necrosis 05/2016 - 02/2009
3	Chronic Hepatitis C 01/2015 - 09/2008
3	Ischemia 07/2014 - 12/2008
3	Infections 03/2012 - 02/2005
2	Squamous Cell Carcinoma (Epidermoid Carcinoma) 02/2024 - 11/2019
2	Neurofibromatoses (Neurofibromatosis) 07/2023 - 01/2010
2	Disease Progression 11/2022 - 01/2021
2	Urinary Bladder Neoplasms (Bladder Cancer) 01/2022 - 10/2008
2	Melanoma (Melanoma, Malignant) 07/2021 - 04/2007
2	Thrombosis (Thrombus) 01/2020 - 06/2008
2	Tetraploidy 01/2018 - 02/2011
2	Glioblastoma (Glioblastoma Multiforme) 01/2018 - 06/2010
2	Colorectal Neoplasms (Colorectal Cancer) 10/2017 - 12/2016
2	Inborn Genetic Diseases (Disease, Hereditary) 01/2017 - 09/2011
2	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2017 - 08/2015
2	Atrophy 08/2015 - 09/2011

Drug/Important Bio-Agent (IBA)

32	Messenger RNA (mRNA)IBA 11/2018 - 03/2002
28	Proteins (Proteins, Gene)FDA Link 01/2023 - 09/2003
14	Biomarkers (Surrogate Marker)IBA 12/2023 - 11/2003
12	Estrogen ReceptorsIBA 01/2023 - 03/2002
8	Estrogens (Estrogen)FDA Link 01/2021 - 03/2002
8	Estrogen Receptor alphaIBA 12/2014 - 04/2003
7	DNA (Deoxyribonucleic Acid)IBA 01/2023 - 10/2003
7	Phenobarbital (Luminal)FDA Link 01/2021 - 08/2014
7	Tamoxifen FDA LinkGeneric 05/2018 - 04/2003
7	RNA-Directed DNA Polymerase (Reverse Transcriptase)IBA 10/2008 - 03/2002
6	palbociclibIBA 01/2023 - 01/2020
6	Phosphotransferases (Kinase)IBA 01/2022 - 05/2003
6	Hormones (Hormone)IBA 11/2019 - 03/2002
6	Transcription Factors (Transcription Factor)IBA 11/2018 - 03/2004
5	Everolimus FDA Link 05/2024 - 08/2014
4	RNA (Ribonucleic Acid)IBA 11/2023 - 09/2003
4	Cyclophosphamide (Cytoxan)FDA LinkGeneric 10/2023 - 12/2012
4	Fulvestrant (Faslodex)FDA Link 11/2022 - 08/2014
4	CytokinesIBA 01/2022 - 06/2004
4	Metalloproteases (Metalloproteinases)IBA 01/2021 - 05/2014
4	Matrix Metalloproteinase 14 (MT1-MMP)IBA 01/2021 - 05/2014
4	Doxorubicin (Adriamycin)FDA LinkGeneric 01/2020 - 12/2012
4	MicroRNAs (MicroRNA)IBA 10/2016 - 01/2011
4	matrigelIBA 07/2015 - 12/2010
4	InterferonsIBA 01/2015 - 02/2005
4	ErbB Receptors (EGF Receptor)IBA 01/2014 - 03/2006
4	LigandsIBA 06/2010 - 09/2003
3	Immune Checkpoint InhibitorsIBA 02/2024 - 12/2019
3	Poly(ADP-ribose) Polymerase InhibitorsIBA 01/2023 - 01/2020
3	Cytidine DeaminaseIBA 12/2022 - 01/2017
3	Aromatase InhibitorsIBA 11/2022 - 01/2019
3	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 10/2022 - 07/2014
3	Circulating Tumor DNAIBA 01/2022 - 04/2019
3	OligonucleotidesIBA 01/2022 - 12/2010
3	Tyrosine Kinase InhibitorsIBA 11/2021 - 06/2011
3	Interleukin-8 (Interleukin 8)IBA 01/2019 - 12/2007
3	Protein Isoforms (Isoforms)IBA 11/2018 - 11/2004
3	Small Interfering RNA (siRNA)IBA 01/2018 - 01/2015
3	Progesterone Receptors (Progesterone Receptor)IBA 01/2018 - 01/2012
3	CholesterolIBA 01/2017 - 07/2009
3	Ribavirin (Virazole)FDA LinkGeneric 01/2015 - 03/2012
3	Estrogen Receptor Modulators (Antiestrogen)IBA 12/2014 - 03/2002
3	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 07/2014 - 06/2004
3	EnzymesIBA 07/2009 - 09/2003
2	pembrolizumabIBA 02/2024 - 12/2022
2	AnthracyclinesIBA 10/2023 - 01/2018
2	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 07/2023 - 01/2021
2	Anastrozole (Arimidex)FDA LinkGeneric 11/2022 - 01/2020
2	Oncogene Proteins (Oncogene Protein)IBA 01/2022 - 11/2019
2	LipidsIBA 01/2022 - 01/2017
2	flotillinsIBA 01/2022 - 01/2018
2	Viral DNAIBA 01/2022 - 11/2019
2	Cetuximab (Erbitux)FDA Link 12/2021 - 04/2015
2	Co-Repressor ProteinsIBA 01/2020 - 04/2003
2	CortactinIBA 12/2018 - 05/2014
2	Apoptosis Regulatory ProteinsIBA 10/2018 - 01/2006
2	WW Domain-Containing OxidoreductaseIBA 10/2018 - 05/2015
2	Celecoxib (Celebrex)FDA Link 01/2018 - 12/2016
2	Cholesterol 24-Hydroxylase (CYP46A1)IBA 11/2015 - 08/2015
2	Amyloid (Amyloid Fibrils)IBA 11/2015 - 08/2015
2	ChemokinesIBA 10/2015 - 12/2007

Therapy/Procedure

37	Therapeutics 05/2024 - 04/2003
15	Drug Therapy (Chemotherapy) 01/2023 - 12/2012
6	Precision Medicine 02/2024 - 04/2016
3	Immunotherapy 12/2023 - 12/2019
3	Injections 12/2021 - 03/2011
2	Proctectomy 02/2024 - 01/2016